Effect of Ayurvedic formulations, Ayush NT capsule and Ayush LK gel in the management of Psoriasis- An open-label, single-arm multicentre study

MANAGEMENT OF PSORIASIS WITH AYUSH NT CAPSULE AND AYUSH LK GEL

Abstract

Psoriasis, a complex chronic immune-mediated inflammatory skin disorder, is influenced by both genetic and environmental factors, leading to persistent cutaneous manifestations that significantly affect patient’s quality of life. Existing systemic and local conventional therapies have limitations due to the chronic nature of the disease, creating a need for innovative interventions. Ayurveda, with its extensive repertoire, offers a promising avenue for exploration in addressing the challenges posed by psoriasis. An open label, single arm, multicentre study was conducted at two Ayurveda Research Institute in India to assess the therapeutic effect of Ayurveda formulations; Ayush NT (Nimbatiktam) capsule and Ayush LK (Lajjalu Keram) g l, in psoriasis. A total of 110 participants aged 18 to 60 years, diagnosed with psoriasis, were enrolled based on predefined selection criteria. All participants were administered Ayush NT capsule twice daily after meals with lukewarm water along with local application of Ayush LK gel on the affected areas twice daily for 24 weeks. Changes in psoriasis area and severity index (PASI) scores, dermatology life quality index (DLQI) questionnaires, and clinical signs and symptoms of the disease were compared before and after the treatment. Data of 108 participants were analysed which revealed significant improvement in PASI and DLQI scores. By day 168, PASI scores reduced from 16.86±8.217 to 6.83±4.449, persisting at 4.43±3.647 by day 196 during follow up also. DLQI showed a notable drop from 21.10±6.232 to 9.13±4.428. No Adverse events reported during trial period. Ayurveda interventions AYUSH NT capsule and AYUSH LK gel showcased good therapeutic potential in improving psoriasis severity and overall quality of life of psoriasis patients which is well tolerated.