A multi-centre study to evaluate the effect and safety of a classical Ayurveda medicine Vyaghri Haritaki in bronchial asthma



  • Milind Suryawanshi CCRAS
  • Vinod Bihari Kumavat CCRAS
  • Pradeep Dua Central Council For Research In Ayurvedic Sciences
  • Babita Yadav CCRAS
  • Shruti Khanduri CCRAS
  • Pallavi Mundada CCRAS
  • Richa Singhal ICMR
  • Rakesh Kumar Rana CCRAS
  • Bharti CCRAS
  • Srikanth Narayanam Deputy Director General




Ayurveda, Respiratory, FEV1, PEFR, Polyherbal, Swasa


Bronchial Asthma (vis-à-vis Tamaka Swasa in Ayurveda) is a chronic inflammatory disorder of the airway. Multiple Ayurvedic formulations are prescribed by Ayurveda physicians for Tamak Swasa. Vyaghri Haritaki is one such commonly prescribed poly herbal classical Ayurvedic formulation.  A Multicentre single-arm study was conducted at three Ayurveda Research Institutes in India to explore the effect and tolerability of Vyaghri Haritaki, a classical Ayurvedic medicine, on Bronchial Asthma (Tamaka Swasa). 147 patients between 18 to 60 years diagnosed with Bronchial Asthma showing a positive test of reversibility of airway obstruction, were enrolled. Patients with peak expiratory flow rate (PEFR) < 50% and/ or Forced expiratory volume in the first second (FEV1) < 50% of the predicted value and other significant co-morbidities were excluded. 10 grams of Vyaghri Haritaki twice daily with lukewarm water was given for 12 weeks (84 days). Changes in the clinical symptoms (Asthma Control Questionnaire), Quality of life (St. George Respiratory Questionnaire), respiratory function (peak expiratory flow rate and forced expiratory volume in one second), and haematological and biochemical parameters were compared before and after the treatment. Data of 142 participants were analysed which revealed significant improvement in PEFR [Baseline 301.7 litres/minute and 84th Day 334.85 litres/minute (p<0.001)], FEV1 [Baseline 1.83 litres and 84th Day 2.12 litres (p<0.001)], Asthma control questionnaire [Baseline 2.95 and 84th Day 1.43 (p<0.001)], and the total score of the St. George Respiratory Questionnaire [Baseline 50.46 and 84th Day 30.74 (p<0.001)]. No adverse events were reported during the study. Vyaghri Haritaki may prove beneficial in improving the pulmonary function, overall symptoms, and quality of life of patients with Bronchial Asthma, which is well tolerated.

Author Biographies

Milind Suryawanshi, CCRAS

Assistant Director

Pradeep Dua, Central Council For Research In Ayurvedic Sciences

Dr Pradeep Dua is a Research Officer at CCRAS, under Ministry of Ayush. He was deputed at Bureau of Indian Standards when this manuscript was drafted and submitted.

He is presently deputed as Tech Officer (P5) -TCI Unit, HIS Deptt., Division of Universal Health Coverage & Life Course, WHO HQ, Geneva, Switzerland.

Babita Yadav, CCRAS

Research Officer

Shruti Khanduri, CCRAS

Research Officer

Richa Singhal, ICMR

Formerly affiliated with CCRAS as Senior Statistics Assistant. Presently Scientist C at ICMR, New Delhi.

Rakesh Kumar Rana, CCRAS

Statistics Officer

Bharti, CCRAS

Director, Central Ayurveda Research Institute, Punjabi Bagh, New Delhi

Srikanth Narayanam, Deputy Director General