A comprehensive review of the therapeutic potential of the ingredients of Aya Bringaraja Panitham, a Siddha medicine for iron deficiency anaemia

Abstract

Anaemia due to iron deficiency is a serious medical condition, especially in children, adolescent girls, and women of reproductive age. Aya Bringaraja Panitham (ABP) is a classical Siddha medicine used to treatiron-deficiency anaemia (IDA). The goal of this study is to compile results from relevant publications, with emphasis on the toxicity, safety, preclinical, and clinical studies of the ingredients in ABP for the treatment of IDA. Data from electronic databases like PubMed, Cochrane, ScienceDirect, Scopus, Google Scholar, and Web of Science, published in English, were collected. The outcome of this article demonstrates the effectiveness of the materials in the ABP formulation and provides evidence of ABP's efficacy & safety in treating IDA. Among 111 articles listed from said databases, 93 were included, and the remaining articles were excluded because they were not related to anaemia, did not discuss the ingredients of ABP, or the haematinic action of ABP ingredients. The included articles comprised 28 literature reviews, 17 studies focused on clinical trials, 23 examined the efficacy, safety, and toxicity of the ingredients, and 25 articles related to IDA.