Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] https://or.niscpr.res.in/index.php/IJNPR <p style="text-align: justify;">Indian Journal of Natural Products and Resources (IJNPR) is a quarterly journal dedicated to exploring topics that confront educators, frontline workers in the fields, entrepreneurs, and ultimate users of the value-added products and their resources of both plants and animals. It publishes original research papers, reviews and short communications. IJNPR was formerly known as <em>Natural Products Radiance </em>(NPR), a bimonthly journal started in 2002.</p> <p style="text-align: justify;"><strong><span class="style1"><span style="font-family: Verdana;">Impact Factor of IJNPR is 0.8 (JCR 2022).</span></span></strong></p> en-US ijnpr@niscpr.res.in (Pramila Majumdar Scientific Editor, IJNPR ) op@niscpr.res.in (Digital Information Resources Division) Wed, 13 Sep 2023 00:00:00 +0530 OJS 3.3.0.13 http://blogs.law.harvard.edu/tech/rss 60 In vitro antidiabetic activities of Myanmar medicinal plants: Cassia siamea Lam. and Butea monosperma Roxb. https://or.niscpr.res.in/index.php/IJNPR/article/view/8670 <p>This study aimed to evaluate the antidiabetic potentials of <em>Cassia siamea</em> and <em>Butea monosperma</em>. Cytotoxic activity of test extracts was performed by a hemolytic assay. Estimation of the antidiabetic properties was explored by α-glucosidase and DPP-IV inhibition assays. The glucose transportation activity of test extracts across the yeast cells was expressed by a glucose uptake assay<strong>. </strong>Non-hemolytic effects of test extracts were shown as lysis per cent less than 15 on RBCs. The inhibition potential of test extracts on α-glucosidase enzyme illustrates that IC<sub>50</sub> values (μg/mL) of <em>C. siamea </em>was 76.33±12.2 and <em>B. monosperma</em> was 77.28±2.02. While the IC<sub>50</sub> values of the acarbose was 36.76±1.55 μg/mL. In addition, the tested extracts showed the ability to inhibit DPP-IV enzyme activity in a concentration-dependent manner. The IC<sub>50</sub> (μg/mL) values of <em>C. siamea, B. monosperma, </em>and the sitagliptin were 117.02±9.73, 103±8.5, and 144.85±13.43, respectively in DPP-IV inhibitory assay. Moreover, the test extracts could transport glucose in yeast cells representing the glucose uptake effectively especially in <em>B. monosperma</em> with a concentration-dependent manner in all tested glucose concentrations. This study provided that the tested extracts promise to possess the antidiabetic potential with non-hemolytic properties, diabetic-enzymes suppressing potency and glucose utilizing ability.</p> Mya Thida, The Su Moe, Khin Nyein Chan, Shun Lai Ei, Aye Aye Khai Copyright (c) 2024 Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] https://or.niscpr.res.in/index.php/IJNPR/article/view/8670 Mon, 19 Feb 2024 00:00:00 +0530 Anti-diabetic potential of fruit extracts of Flacourtia indica (Burm. F.) Merr-An in-vitro study https://or.niscpr.res.in/index.php/IJNPR/article/view/8659 <p>Diabetes mellitus is one of the biggest global health problems requiring preventive and new therapeutic interventions. There is a need for safe, reliable, and cost-effective anti-diabetic drugs, and investigating medicinal plants for new anti-diabetic medications is an exciting research field. Thus, the present study examined the <em>in-vitro</em> anti-diabetic activity of ethanolic and aqueous extracts of <em>Flacourtia indica </em>(Burm. F.) Merr (Flacourtiaceae) fruits by different enzyme inhibition assay methods. Alpha-amylase and Alpha-glucosidase are the principal enzymes present in the human body which helps in the digestion of carbohydrates. Inhibition of these enzymes slows down the absorption of glucose and lowers the sugar level in the blood. Both extracts showed potent inhibitory activity against these enzymes in a dose-dependent manner. The highest percentage of inhibition is exhibited by ethanolic extract at a concentration of 100 µg/mL with an IC<sub>50</sub> value of 84.02. The results were compared with the standard drug Acarbose, a competitive inhibitor of both enzymes. The ethanolic extract was subjected to preliminary phytochemical analysis to find out different chemical constituents. It revealed the presence of reducing sugars, flavonoids, phenolic compounds, terpenoids, fatty acids, and steroids. Therefore, the current study proved that both ethanolic and aqueous extracts of <em>F. indica</em> fruits possess bioactive constituents that could be responsible for the anti-diabetic activity.</p> Sudhina Makuttan, Jennifer Fernandes, Ambily P G Copyright (c) 2024 Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] https://or.niscpr.res.in/index.php/IJNPR/article/view/8659 Mon, 19 Feb 2024 00:00:00 +0530 The effects of methanolic extract of Uncaria gambir against microflora of dental caries https://or.niscpr.res.in/index.php/IJNPR/article/view/8669 <p>The antibacterial effects of <em>Uncaria gambir</em> extract have the potential to be expanded in dentistry, mainly in the management of dental caries and its sequelae. This preliminary study was conducted to investigate the <em>in vitro</em> antibacterial activity of methanolic extract of <em>U. gambir</em> against dental caries-related microflora: <em>Streptococcus mutans, Streptococcus sobrinus, Lactobacillus casei</em> and <em>Enterococcus faecalis.</em> The methanolic extract of <em>U. gambir</em> in powder form was dissolved and serially diluted in 1% dimethyl sulfoxide. The antibacterial effects of the extract were determined using the broth microdilution technique. A transmission electron microscope (TEM) was used to assess the effects of the extract on the morphology of the bacteria. A 0.12% chlorhexidine (CHX) and Man-Rogosa-Sharpe/brain heart infusion broth were used as positive and negative control respectively. Greatest antibacterial effects were seen on both Streptococci species with the minimal inhibitory concentration (MIC) and minimal bactericidal concentration (MBC) values of 1.25 and 5 mg/mL respectively, followed by <em>Enterococcus faecalis</em> (MIC=2.5 mg/mL, MBC=10 mg/mL) and <em>Lactobacillus casei</em> (MIC=7.5 mg/mL, MBC=30 mg/mL) in ascending order. Cell wall damage of all bacteria at their respective MIC value was observed through the TEM analysis. Tukey’s posthoc test showed no statistically significant difference in the antibacterial activity exerted by <em>U. gambir</em> extract and 0.12% CHX, with <em>P</em>&gt; 0.05. Conclusively, <em>U. gambir </em>extract exhibits a good antibacterial effect against the microflora of dental caries and carries great potential for future development.</p> Nur Fazwani Ahmad Murad, Alida Mahyuddin, Zaleha Shafie, S Nagarajan MP Sockalingam, Ahmad Shuhud Irfani Zakaria Copyright (c) 2024 Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] https://or.niscpr.res.in/index.php/IJNPR/article/view/8669 Mon, 19 Feb 2024 00:00:00 +0530 Phytochemical analysis, biological activities, and GC profiling of extracts of some medicinal plant growing in Nepal https://or.niscpr.res.in/index.php/IJNPR/article/view/8671 <p>The present study was aimed to determine the antioxidant, α amylase inhibition, and antibacterial activities on ten traditionally used medicinal plant extracts, namely <em>Cyperus rotundus</em>, <em>Citrus medica</em>, <em>Gaultheria fragrantissima</em>, <em>Jasminum humile</em>, <em>Osyris wightiana</em>, <em>Buddleja asiatica</em>, <em>Berberis aristata</em>, <em>Robus ellipticus</em>, <em>Schima wallichii</em>, and <em>Smilax ovalifolia </em>growing in Nepal. The bioactive fraction of <em>J. humile</em> was subjected for GC analysis. The free radical scavenging properties of plant extracts were assessed using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and antibacterial activity was performed by the well diffusion method. The antidiabetic activity was assessed α amylase inhibition assay. The chemical compounds were isolated from the active plant fraction by silica column chromatography, and the collected fractions were analyzed by GC and FTIR. The phytochemical analysis showed that plant extracts were rich sources of secondary metabolites. The <em>in vitro </em>antioxidant activity showed IC<sub>50</sub>&nbsp;ranging from 30.57±0.02 to 155.65±0.10 µg/mL. The promising antioxidant activity was demonstrated by <em>S. wallichii </em>of IC<sub>50</sub> 30.57±0.02 µg/mL and <em>J. humile</em> 35.28±0.54 µg/mL, respectively whereas, the <em>S. ovalifolia</em>, exhibited the moderate antioxidant activity of IC<sub>50 </sub>155.65±0.10 µg/mL. The <em>J. humile </em>showed significant antidiabetic activity of IC<sub>50</sub> 59.4±23.47 µg/mL. The antidiabetic activities exhibited ranged from IC<sub>50</sub> of 77.29±2.05 (<em>S. wallichii </em>to 608.28±71.50 µg/mL (<em>C. rotundus</em>). The <em>R. ellipticus</em> showed maximum ZOI (22 mm) against the <em>Staphylococcus aureus </em>(ATCC 25923), whereas <em>J. humile</em> (20 mm), <em>O. wightiana</em> (18 mm), and <em>G. fragrantissima</em> (16 mm) showed moderate antibacterial activity against the <em>S. aureus</em>. The <em>C. rotundus</em>, <em>J. humile</em>, <em>S. ovalifolia</em>, <em>O. wightiana</em>, and <em>B. asiatica</em> showed promising antibacterial activity against <em>E. coli</em> (ATCC 25922) with ZOI 15, 17, 14, 17, and 18 mm respectively. These findings provide partial scientific support for traditional uses of these medicinal plants against diabetes and infectious diseases. Therefore, the <em>J. humile</em> could be a promising source of natural antidiabetic and antioxidant compounds that may be drug candidates for future drug development. To the best of our knowledge, this work is the first attempt to perform all these biological activities and phytochemical analyses growing in the particular region of Nepal.</p> Rama Banjara, Khaga Raj Sharma, Yuba Raj Pokharel Copyright (c) 2024 Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] https://or.niscpr.res.in/index.php/IJNPR/article/view/8671 Mon, 19 Feb 2024 00:00:00 +0530 Pharmacognostic, phytochemical analysis and in-vitro antioxidant activity of Senecio edgeworthii Hook plant https://or.niscpr.res.in/index.php/IJNPR/article/view/8665 <p>The objective of the present study was to investigate pharmacognostic, phytochemical and evaluate <em>in vitro</em> antioxidant properties of <em>Senecio edgeworthii</em> hook Plant. The study of leaf macroscopic features, microscopic features was undertaken and physicochemical parameters were evaluated using standard procedures as per WHO guidelines. <em>In vitro</em> antioxidant activity of <em>S. edgeworthii</em> plant was determined by application of standard methods. In microscopy of <em>S. edgeworthii</em>, leaf is having Upper epidermis, cuticle, multicellular covering trichomes. The transverse view of the lamina shows a single layer of closely packed palisade cells below the upper epidermis. In powder characteristics analysis, lignified xylem parenchyma, lignified fibres, stomata, epidermis, cork cell, xylem vessels, spiral vessels and trichomes were observed. A low amount of total ash acid insoluble ash and water-soluble ash indicate that the inorganic matter and non-physiological matter such as silica is less <em>S. edgeworthii</em> plant. The estimation of total phenolic content in the examined extracts showed SE-Chloro and SE-alcohol extract contains high phenolic content than SE-Oil and SE-Pet ether. The results of antioxidant evaluation based on the three models (DPPH, H<sub>2</sub>O<sub>2</sub>, and NO) used in this study revealed that chloroform and alcohol extract and flower oil of <em>S. edgeworthii</em> plant possess interesting antioxidant activity. The pharmacognostic, phytochemical analysis can contribute to the development of the quality control norms for this species. This plant may possess considerable antioxidant activities.</p> Vikas S. Shende, Jagdish L. Kakadiya Copyright (c) 2024 Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] https://or.niscpr.res.in/index.php/IJNPR/article/view/8665 Mon, 19 Feb 2024 00:00:00 +0530 Fingerprints of two medicinal species of Alternanthera – A. ficoidea and A. sessilis to facilitate differentiation in dried form https://or.niscpr.res.in/index.php/IJNPR/article/view/8662 <p><em>Amaranthaceae </em>family members are of folkloric importance. Present work aims to evaluate differentiation between two species <em>Alternanthera ficoidea</em> and <em>Alternanthera sessilis</em>. Plant samples were collected and authenticated. Powder microscopy, phytochemical, physicochemical, HPTLC photo documentation &amp; fingerprint profiling (<em>n</em>-hexane, successive chloroform, successive ethanol) and HPLC analysis of both samples were performed. Powder microscopic studies of both species were carried out and the characteristic features were captured and documented. Physico-chemical investigation divulged the different ash content of two species. Phytochemical investigation revealed the variance of secondary metabolites in different extracts of the samples. Photo documentation as well as fingerprint profile by HPTLC followed spectral comparison and HPLC analysis confirmed the presence of common compounds in different extracts of the selected species.</p> Achintya Kumar Mandal, Divya Kallingil Gopi, Sunil Kumar Koppala Narayana, Habeebmon K C, Shakila Ramachandran Copyright (c) 2024 Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] https://or.niscpr.res.in/index.php/IJNPR/article/view/8662 Mon, 19 Feb 2024 00:00:00 +0530 Hemisynthesis and evaluation of pharmacological activities of carvacrol-derivatives https://or.niscpr.res.in/index.php/IJNPR/article/view/8645 <p>Hemi-synthesis, a process widely used in pharmacological research, consists of a modification in the chemical structure of a natural product in order to improve its activity and/or to reduce its side effects. Two carvacrol-derivatives (P1 and P2) have been synthetized using reactions of alkylation by binding alkan groups at the hydroxyl group of carvacrol. NMR analysis was performed for synthetized derivatives to confirm the success of the reactions. Then, cytotoxic activity, against two tumour cell lines (P-815 and MCF-7), and antibacterial activity of carvacrol, P1 and P2 were performed. Cytotoxicity was measured using the colourimetric methyl tetrazolium test (MTT) and antimicrobial activity was measured using the diffusion technique on solid media and the determination of CMI on liquid media. Our results show that chemical modifications made on carvacrol have no effect on its antitumor activity. However, an important decrease of its antibacterial activity was observed, especially for P1. Our results suggest that hydroxyl group at this position of the molecule may be responsible for carvacrol antibacterial activity, while the other parts of the molecule may be responsible for its antitumor activity. On the other hand, introduced modifications may affect mechanism of action of the molecules as well as its pharmacokinetics properties.</p> Abdeslam Jaafari, Souad Lekchiri, Mounir Tilaoui, Moulay Ali Oukerrou, El Mostapha Rakib, Hassan Ait Mouse, Abdelmajid Zyad Copyright (c) 2024 Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] https://or.niscpr.res.in/index.php/IJNPR/article/view/8645 Mon, 19 Feb 2024 00:00:00 +0530 Development of plant based nanoemulsion and its application as natural preservative having antioxidant and antimicrobial properties to deliver active compounds in apple juice https://or.niscpr.res.in/index.php/IJNPR/article/view/8651 <p>In this study, active compound loaded stable nanoemulsion (surface charge -18 mV) was developed having small diameter (&lt;100 nm) from the plant extract of raw&nbsp;<em>Syzygium aromaticum</em>,&nbsp;<em>Ocimum tenuiflorum&nbsp;</em>and<em>&nbsp;</em>rhizome of&nbsp;<em>Zingiber officinale</em>. The antimicrobial and antioxidant properties of formulated nanoemulsion were analyzed. The nanoemulsion showed good antimicrobial activity against various food poisoning organisms <em>viz.</em> bacteria (<em>Staphylococcus </em><em>aureus </em>and <em>Escherichia</em> <em>coli</em>) and fungi (<em>Candida albicans</em>). For the antioxidant study, two different methods 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic 167 acid) diammonium salt (ABTS) were used, and a satisfactory result achieved (% inhibition for DPPH: 63.64±1.85 and ABTS: 48.36±1.12). The nanoemulsion in combination with a low dose of benzoic acid (200 ppm) is used as a preservative in formulated apple juice. The formulated juice quality was analyzed compared with standard fruit juice during a storage period of 30 days and quality of fruit juice remained good. This method thus allows reducing the use of synthetic preservatives with added benefit of natural beneficial compound in the formulated juice for human consumption.</p> Kailash Barman, Devasish Chowdhury, Pranjal K. Baruah Copyright (c) 2024 Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] https://or.niscpr.res.in/index.php/IJNPR/article/view/8651 Mon, 19 Feb 2024 00:00:00 +0530 GC-MS analysis and qualitative phytochemical screening of Aristolochia assamica, a newly discovered rare medicinal plant species of India https://or.niscpr.res.in/index.php/IJNPR/article/view/8668 <p><em>Aristolochia assamica </em>D. Borah &amp; T.V. Do, is an ethnomedicinal plant and a new record to Indian flora. Through this study, the presence or absence of secondary metabolites was screened and the presence of alkaloids, glycosides, flavonoids, phenolic compounds, terpenoids and tannin was established. The chromatograph of the GC-MS analysis of the methanolic leave extract showed the presence of various compounds mainly 2-Octylcyclopropene-1-heptanol, α-ylangene, 6,10,14,18,22-Tetracosapentaen-2-ol, 3-bromo-2,6,10,15,19,23-hexamethyl-, (all-E)-, (Z)-7-Hexadecenal, 1-Naphthalenemethanol, 1,4,4a,5,6,7,8,8a-octahydro-2,5,5,8a-tetramethyl-, 3-Hexadecyne with highest area percentage. These compounds are recorded for the first time in this plant. Further researches related to pharmacological activities and isolation of the phytocompounds from <em>A. assamica </em>may help in the novel drug designing and development.</p> Punam Jyoti Borah, Ruma Sarma Copyright (c) 2024 Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] https://or.niscpr.res.in/index.php/IJNPR/article/view/8668 Mon, 19 Feb 2024 00:00:00 +0530 The effect of ingredients’ concentration on nanoemulsion particle size of eucalyptus essential oil https://or.niscpr.res.in/index.php/IJNPR/article/view/8672 <p>This study aimed to determine the effect of different parameters affecting the particle size of eucalyptus-essential oil nanoemulsion using artificial neural networks. The formulation of nanomaterials used in this study included Tween 80 (as surfactant), ethanol (as co-surfactant), and eucalyptus essential oil (as internal phase), in water. To prepare the nanoemulsion, the mixtures were sonicated and the size of resulting nanoparticles were measured using dynamic light scattering (DLS). Then, the data were modelled using artificial neural networks. The results revealed that high Tween 80 concentration and low essential oil concentration had positive effects on reduction of particle size, while the change in ethanol concentration had no obvious impact on the size. The prepared nanoemulsions has the potential to be used in biomedical applications.</p> Ailin Ebrahimzadeh, Amir Amani Copyright (c) 2024 Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] https://or.niscpr.res.in/index.php/IJNPR/article/view/8672 Mon, 19 Feb 2024 00:00:00 +0530 Optimization of carrageenan production from Persian Gulf algae Laurencia obtusa: Purification and rheological characterization https://or.niscpr.res.in/index.php/IJNPR/article/view/8657 <p>In this study, <em>Laurencia obtusa </em>(Yamada, 1931) species was investigated for carrageenan extraction. <em>L. obtusa </em>species was identified using the molecular barcoding method with two COI and rbcL genes. Rheological analysis was performed to determine the rheological properties of semi-refined carrageenans. Experimental design was carried out with Design Expert software to produce and optimize SRC extraction. The software presented 18 treatments based on temperature, cooking time and concentration of KOH. Treatments were prepared for rheometric analysis (i.e., viscosity measurements). Optimization was performed by the software with maximum viscosity. Also, two refined carrageenan extraction methods were performed, and the FTIR and NMR spectra were compared. Barcoding showed similarity values of 96 and 94% using the COI sequence and therbcL sequence, respectively. The optimal treatment included temperature of 77°C, 99 minutes, and 7% concentration of w/v KOH. The highest efficiency was associated with the dialysis method, which was 19%. Based on the rheometric analysis, the SRC solution was introduced as a pseudo plastic Non-Newtonian fluid. According to these two analyses, the refined carrageenans of <em>L. obtusa </em>were of the iota type.</p> Tayebeh Entezari, Mandana Zarei, Ahmad Azari Copyright (c) 2024 Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] https://or.niscpr.res.in/index.php/IJNPR/article/view/8657 Mon, 19 Feb 2024 00:00:00 +0530 Formulation and evaluation of herbal lipstick from pigment of Nyctanthes arbor-tristis https://or.niscpr.res.in/index.php/IJNPR/article/view/8653 <p>The Herbal lipsticks are composed of natural colourants and compounds to protect the lips. The market place for organic products in various fields extends throughout the world on account of increased awareness among consumers of side effects related to protracted use of some synthetic colouring compounds, and therefore the current trend towards healthful biomaterials in products. This work aimed to formulate a natural lipstick from coloured pigments of <em>Nyctanthes arbor-tristis </em>(Night flowering jasmine<em>) </em>flowers. The use of natural colouring pigments in the product would minimize the side effects. This study focused on the extraction of colourant from <em>N. arbor-tristis </em>flowers and optimizing the formula for the preparation of lipstick and evaluating it. The results indicate that the prepared formulation was good and had minimal or no side effects on the lips.</p> Harsini Venkatachalam, Chidambara Rajan Parameswaran, Radha Palaniswamy Copyright (c) 2024 Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] https://or.niscpr.res.in/index.php/IJNPR/article/view/8653 Mon, 19 Feb 2024 00:00:00 +0530 A review of the nutritional potential of edible snails: A sustainable underutilized food resource https://or.niscpr.res.in/index.php/IJNPR/article/view/8658 <p>Despite the use of snails as food in many different communities in the world, the consumption of snail meat is still far from being appreciated. The authors compiled and reviewed the nutrient composition of edible snail meat based on the available scientific literature. The protein, fat, and ash content of snail meat were found to be 14.0, 1.4 and 2.1% on the basis of fresh matter respectively. Comparable protein content with conventional foods of animal origin along with the presence of all essential amino acids and less carbon footprint makes the snail meat a sustainable food source. Moreover, less fat content but higher proportion of polyunsaturated fatty acids, and considerable presence of minerals with nutritional importance especially calcium, zinc, and iron could exhibit human nutritional benefits. However, the establishment of heliciculture facilities is a necessity in order to support this sustainable food resource&nbsp;and also enhance the economic condition of certain local areas.</p> Mahendra Baghele, Shubhi Mishra, Victor Benno Meyer-Rochow, Chuleui Jung, Sampat Ghosh Copyright (c) 2024 Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] https://or.niscpr.res.in/index.php/IJNPR/article/view/8658 Mon, 19 Feb 2024 00:00:00 +0530 Bio-evaluation studies of phytoconstituents- A review of the patents granted and filed by CSIR https://or.niscpr.res.in/index.php/IJNPR/article/view/8654 <p>Botanicals have become a very important part of our life and are increasingly used as a primary source of actives in pharmaceuticals, cosmetics, nutraceuticals and personal care products. Extensive studies have been conducted on botanicals to understand their chemical profile and most of them have a history of safe use. Technical advances to isolate the bioactives, determine their molecular structure as well as their mechanism of action has generated considerable data and are available in the form of scientific publications as well as filing of patents. In this review, we aim to present the information pertaining to therapeutic applications of bioactives from different medicinal plants as disclosed in filed and granted patents to one of the largest publicly funded organizations in India namely Council of Scientific and Industrial Research (CSIR). The review also presents an assignee focused analysis and provides insights into the level of patent filing activity in the area of bioactives and the therapeutic applications by CSIR, India. Such information can provide a valuable tool for exploiting a firm’s portfolio of patent holdings to assist decision-makers to identify the most valuable patents; product area or business opportunities among its own patent holdings.</p> Sivakami Dhulap, Anita Mandhare, Kashmira Deval Copyright (c) 2024 Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] https://or.niscpr.res.in/index.php/IJNPR/article/view/8654 Mon, 19 Feb 2024 00:00:00 +0530 Efficacy of phyto-therapeutics in allergic rhinitis: A review https://or.niscpr.res.in/index.php/IJNPR/article/view/8650 <p>Allergic rhinitis (AR) or hay fever is the most common symptomatic allergic disorder triggered by allergen and if it remains undiagnosed, can adversely impact the general well-being. The ailment is characterized by an exaggerated immune response to environmental triggers including pollen, moulds, ragweed, dirt mites, dust, etc. within the nasal mucosa, ultimately leading to gene environment interaction which elevate the IgE level in the nasal mucosa, and ultimately infection of the nasal cavity. The major signs and symptoms of AR include rhinorrhea, sneezing, eye itching, postnasal drip, cough, nasal obstruction, and fatigue due to nasal discomfort. Various studies reported 20-30% occurrence of the disease and majority of them are inclined towards allopathic medication for instant relief. Since these drugs lead to unenviable side effects in the long term, it is of utmost importance to search for alternative mode of medication with lower side-effects. The use of traditional medication in the form of various herbal plants and their mixture have proved to be effective in the management of symptoms for asthma and AR. Their efficiencies have been restrained successfully in various reports. It&nbsp;has been proven that herbal medicines are safe to use and thus have rendered a vast contribution to the treatment of allergic rhinitis. Hence, the present review is aimed to discuss the efficacy and protection provided by diverse herbal drugs in the management of AR.</p> Rakhi Gupta, Archana Aggarwal, Kamakshi Upreti, Shreya Rawat, Bhumika Tiwari, Radhika Copyright (c) 2024 Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] https://or.niscpr.res.in/index.php/IJNPR/article/view/8650 Mon, 19 Feb 2024 00:00:00 +0530 Plant products as an alternative phytotherapeutics to regulate thrombosis – A review https://or.niscpr.res.in/index.php/IJNPR/article/view/8661 <p>Thrombosis, a life-threatening disease causes thrombus formation within blood vessels to obstruct the flow of blood through vascular system. The disease causes morbidity and mortality of arterial and venous thrombosis which can result in acute infraction and deep vein thrombosis. Majority of clotting factors are serine proteases and are present as precursors of proteolytic enzymes known as zymogens that circulate in inactivated forms but get activated in response to injury in blood vessels. The serine proteases are involved in coagulation, anticoagulation, and fibrinolysis. Thrombin and fibrin are the main key therapeutic target for the treatment of thrombosis. Commercially available antithrombotic and thrombolytic drugs are known to be associated with serious side effects like bleeding, hypertension, and haemorrhage therefore natural products have been suggested as best replacement of synthetic antithrombotic and thrombolytic drugs with less side effects for human health. Plants have been suggested as potential source of anticoagulants against thrombosis with fewer or no side effects.</p> Sawetaji, Kamal Krishan Aggarwal Copyright (c) 2024 Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] https://or.niscpr.res.in/index.php/IJNPR/article/view/8661 Mon, 19 Feb 2024 00:00:00 +0530 An invasive plant Sonchus asper (L.) Hill: A review of its ethnopharmacology, phytochemistry, and pharmacological properties https://or.niscpr.res.in/index.php/IJNPR/article/view/8655 <p>India is well known for medicinal plants because of rich plant biodiversity. Kumaun Himalayan region of Uttarakhand state occupies a great place in having good number of medicinal plants. The uses of plants in the indigenous cultures of developing countries are numerous and diverse. In a developing country, 65% population is dependent upon traditional medicinal system. The plant based traditional medicinal system play an important role in curing the health from various diseases all over the world. The present review reveals the updated information regarding the ethnopharmacology, phytochemistry, and pharmacological properties of an invasive plant <em>Sonchus asper</em> (L.) Hill. For this study, an extensive and intensive field survey by visiting the nearby villages of Nainital district was carried out along with detailed literature survey. Multitudinous ethnic properties and pharmacological study may help in development of new drug for the treatment of cancer and infectious diseases from this plant. The documentation of isolated compounds may afford new drug entity for pharmacy sector with lesser cost and more efficacy.</p> Amrendra Nath Tripathi, Suresh Chandra Sati , Parikshit Kumar Copyright (c) 2024 Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] https://or.niscpr.res.in/index.php/IJNPR/article/view/8655 Mon, 19 Feb 2024 00:00:00 +0530 The impact of walnut leaf on the lipid and glucose profiles in diabetic patients: A systematic review and meta-analysis https://or.niscpr.res.in/index.php/IJNPR/article/view/8660 <p>Managing risk factors associated with cardiovascular diseases, such as blood lipids and blood sugar in people with diabetes (PWDs), is important. Besides antidiabetic medicines, herbal remedies such as walnut leaves have long been utilized to decrease blood sugar and blood lipid levels in PWDs. Hence, this study aimed to investigate the impact of walnut leaf on the lipid and glucose profiles of PWDs through a systematic review and meta-analysis. To gain access to the primary empirical studies, domestic and international databases were searched using MeSH keywords. The databases included Barakat Gostar, SID, Magiran, IranDoc, PubMed, Scopus, Web of Science, Embase, Cochrane, International Standard Randomized Controlled Trial Number (ISRCTN), International Clinical Trials Registry Platform (ICTRP), and Clinical Trial.gov (a clinical trial registration system). Data analysis was performed within Stata 14 software. The <em>P</em>-value was considered <em>P</em> &lt;0.05. In 4 studies with a sample size of 101 individuals, which were published between 2014 and 2018, post-test scores of the treatment and control groups pointed out that the difference between insulin and FBS levels was statistically significant. The FBS level was higher in the control group than in the treatment group. However, their insulin level was lower than those in the treatment group. The difference between the levels of HbA1C, cholesterol, triglyceride, LDL, HDL, AST, ALT, ALP, and creatinine in the control and treatment groups was not statistically significant. The pre and post-test scores of the treatment group were compared. The levels of FBS, HbA1C, and LDL decreased significantly, while the patients' insulin levels increased remarkably. No noticeable correlation was observed in other lipid profiles. Due to the thoroughly limited research resources, further studies are required to confirm the findings more confidently.</p> Moloud Fakhri, Seyde Sedighe Yousefi, Mahmood Moosazadeh, Mohammad Azadbakht, Hafez Fakheri Copyright (c) 2024 Indian Journal of Natural Products and Resources (IJNPR) [Formerly Natural Product Radiance (NPR)] https://or.niscpr.res.in/index.php/IJNPR/article/view/8660 Mon, 19 Feb 2024 00:00:00 +0530