Therapeutic efficacy of Majoon-e-Aarad Khurma (poly-herbal formulation) in anaemia associated with hypothyroidism: A randomized placebo-controlled clinical trial

MAJOON-E-ARAD KHURMA IN HYPOTHYROIDISM ASSOCIATED ANAEMIA

Abstract

Hypothyroidism and anaemia frequently coexist and may complicate clinical management, particularly in patients who experience intolerance or difficulty with conventional therapy. The present study was undertaken to evaluate the therapeutic efficacy of Majoon-e-Aarad Khurma, a traditional Unani polyherbal formulation, in anaemia associated with hypothyroidism. A single-blind, randomized, placebo-controlled clinical trial was conducted on 50 participants, who were allocated in a 2:1 ratio to receive either Majoon-e-Aarad Khurma or placebo for 45 days. Hematological parameters including hemoglobin (Hb), red blood cell count (RBC), packed cell volume (PCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), mean corpuscular volume (MCV), and red cell distribution width (RDW) were assessed as primary outcomes, while thyroid hormone levels (T3, T4) and thyroid-stimulating hormone (TSH) were evaluated as secondary outcomes. Although some within-group changes were observed, no statistically significant improvement was found in hematological parameters or thyroid hormone profile when compared with placebo. The findings suggest that Majoon-e-Aarad Khurma, when used as an adjunct for 45 days, did not produce significant therapeutic benefit in anaemia associated with hypothyroidism under the conditions of the present study. Further studies with larger sample size, longer duration, and more targeted patient stratification may be required to better evaluate its clinical potential.