Antimicrobial potential of polyvinyl pyrollidone stabilized silver nanoparticles synthesized by Sphingobacterium multivorum

Abstract

The main objective of this study was to develop ecofriendly and stable silver nanoparticles (AgNPs) with antimicrobial potential. AgNPs were synthesized using Sphingobacterium multivorum supernatant and characterized by UV-Visible spectrophotometric analysis, X-Ray Diffraction analysis, Transmission electron microscopy, Fourier transform infrared and Dynamic Light scattering. Biosynthesized AgNPs exhibited broad spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria. Minimum inhibitory concentration was detected 19.5 µg for E. coli and S. aureus. AgNPs have exhibited significant synergistic effect with all the selected antibiotics. The present study demonstrated  a rapid, economic and ecofriendly method for the synthesis of stable AgNPs and further evaluation of the antimicrobial activity against Gram-positive and Gram-negative bacteria.