Synthesis, Characterization, Antimicrobial, Anti-Diabetic, Anti-Inflammatory and Anti-Cancer studies of Schiff Base metal(II) complexes derived from Mixed Schiff base ligand

Abstract

A new Schiff base ligands (L¹ & L²) was prepared from cinnamaldehyde with aniline  (L¹) and 4-Hydroxy-3-methoxybenzaldehyde with O-Nitro aniline in 1:1 molar ratio. The mononuclear metal(II) complexes [ (ML¹L²)]  [ M= Co(II), Ni(II), Cu(II) and Zn(II)] were synthesized & characterized. ML¹L² synthesized from Ligand (L¹), metal salts and Ligand (L²) molar ratio is 1:1:1. Elemental analyses, IR, NMR, Electronic spectra,  SEM and  molar conductivity are need to clarify the structure of synthesized metal(II) complexes. The square planar geometry is proposed for CoL¹L²,  NiL¹L² and ZnL¹L², distorted square planar geometry for CuL¹L² complex. Antibacterial activity of Ligands, ML¹L² were screened against bacterium Gram(+), Gram(-) & antifungal activity was determined against fungus. The anti-inflammatory and anti-diabetic actions of the L¹, L² , CuL¹L²complexes were studied. The anticancer activity of L¹, L² and CuL¹L² were studied opposed to MCF-7 using MTT assay method.