Ultrasound-assisted bio-derived ZnO NPs, CuO NE NPs, and ZnO-CuO NCs; its characterization and antibacterial evaluation. Proficient ZnO-CuO NC: Eco-conscious Generation of 3,4-dihydropyrimidine-2(1H)-ones under solvent-free technique.

Abstract

ZnO NPs, CuO NPs, and ZnO-CuO NCs were synthesized from aqueous extract of Azadirachta indica (neem leaves) plant extract by co-precipitation method in aqueous medium, under ultrasound irradiation has been developed. The traditional medicinal tree that is Neem (Azadirachta indica) leaf extract and ultrasound irradiation have a elementary aspect in the formation of different morphologies of ZnO NPs, CuO NPs, and ZnO-CuO NCs. The significant antibacterial activity of synthesized NPs was carried out against bacteria namely E.coli and S.aureus and concluded that; they have a good ability to resist growth of bacteria. Among the synthesized nanoparticles bimetallic nanoparticles have drawn a greater extent than monometallic nanoparticles. The enhancement could be due to the synergy between ZnO and CuO NPs. Hence, ZnO-CuO NCs used to productive synthesis of dihydropyrimidones derivatives under solvent-free technique is described. The environmental friendliness and reusability of the catalyst with steady activity, short reaction time, simple filtration process for separation of catalyst, simplexes product isolation, make this protocol attractive in organic synthesis.