Synthesis, Characterization and Antimicrobial studies of novel Schiff base and its 3d series Metal Complexes

Abstract

This paper describes the synthesis, characterisation, and antimicrobial evaluation of a Schiff base ligand 3-hydroxy-4-[(1E)-[(6-sulfanylpyrimidin-4-yl)imino]methyl]benzonitrile (LH), as well as its Mn(II), Fe(II), Co(II), Ni(II), Cu(II) and Zn(II) metal complexes. The ligand was created by combining 6-aminopyrimidine-4-thiol and 4-formyl-3-hydroxybenzonitrile in ethanol under reflux conditions, using acetic acid as a catalyst. The production of the ligand and its complexes was validated using spectroscopy and other analytical methods. The antibacterial activity of these compounds was tested against Gram-positive and Gram-negative bacterial strains utilizing agar diffusion techniques. Additionally, antifungal activity was tested against T. reesei and C. albicans using the agar well diffusion technique. The generated metal complexes exhibited higher antibacterial activity than the free ligand, implying potential uses in antimicrobial drug development.