Rare Earth transition metal-based coordination compounds of Schiff base derived from sulpha drug molecules: Synthesis, spectroscopic and in vitro biological screening

Sulpha drug based Coordination compounds

Abstract

In order to create novel transition metal-based coordination compounds, Schiff bases based on the sulpha drug reacted with various 2-hydroxy-benzaldehyde derivatives. The antibacterial properties and spectroscopic attributes of the synthesized ligands and their heterochelates were extensively examined. The structural characterization of the ligands was accomplished through ¹H-NMR, IR, mass spectrometry, UV-Vis spectroscopy, and elemental analysis, while the heterochelates' structures were validated using IR spectroscopy. In vitro evaluations were conducted to assess the activity of the ligands and heterochelates against Gramme +ve bacteria (S. aureus, B. subtilis), Gramme -ve bacteria (E. coli, P. aeruginosa), and against fungi A. niger. The findin0gs underscore the promising nature of coordination compounds based on transition metals and highlight the necessity of furth00er exploration in this field.