Transition metal based coordination compounds of Schiff base derived from drug molecules: Synthesis, Spectroscopic and In-Vitro biological screening

Abstract

In order to create novel transition metal-based coordination compounds, Schiff bases (SB) based on the therapeutic molecules ambroxol and imitinib amine were reacted with 5-Methyl-2-furaldehyde. We investigated the antibacterial and spectroscopic characteristics of all the synthesised SB ligands and its coordination compounds. The SB ligand coordination compounds were validated by IR and FAB mass spectroscopic analysis and the ligand structures were established by ¹H NMR, IR, mass and elemental analysis. All SB ligands and coordination compounds were tested in vitro on both Gram-positive (Staphylococcus epidermidis, Bacillus subtilis) and Gram-negative (Escherichia coli, Salmonella enterica) bacteria. The outcomes showed how promising transition metal-based coordination compounds are and how crucial it is to conduct more study on them.