The Efficient Synthesis, Molecular Docking and Biological Evaluation of Novel Isatine linked Spiroheterocycle through Multi-Component Reaction

Molecular Docking And Synthesis of Isatine linked Biologically Active Molecules through Multicomponent Reactions.

Abstract

            : In this work , newly twelve -Compounds synthesized by One Pot N-Mannich base Multicomponent reaction .The synthesized compounds were characterized by using FT-IR, H¹-NMR , C¹³- NMR And  Mass Spectrometry .The final compounds were evaluated for their in vitro Antibacterial  Activity and Antifungal Activity using  Agar-well Diffusion method. The tested compounds show poor to good activity with Inhibition zone value between 8 to 25 mm, when compared to reference Ciprofloxacin and Flocanazole. Among them compounds 6b,6c,6d and 6g show most promoting activity against E.coli, B. cereus, B.substilis and A.Niger, R.Nigricans.