Convergent and efficient synthesis of 1,2,4-triazolo[5,1-b]quinazolin-8-ones using copper incorporated hydroxyapatite encapsulated Kit-6 as a recoverable nanocatalyst

Abstract

Copper incorporated hydroxyapatite encapsulated Kit-6 (Cu@HAp@KIT-6) has been used as an effective nanocatalyst in the synthesis of 1,2,4-triazolo[5,1-b]quinazolin-8-one derivatives by a one-pot reaction of 3-amino-1,2,4-triazole, dimedone and aromatic aldehydes in ethanol. This novel protocol affords the products under optimized reaction conditions with high to excellent yields (88-97%) and lower reaction times (40-50 min). Wide substrate scope, facile work-up procedure, reduced reaction time, the use of green solvent and recyclability of the catalyst are some prominent advantages of this protocol. The catalytic activity of the catalyst after six consecutive runs has been preserved without an appreciable decrease in its activity.