Cardio protective activity of Sargassum wightii on isoproterenol induced myocardial stress in rats

Abstract

The aim of this investigation is to determine whether the methanolic extracts of Sargassum wightii can protect rats against isoproterenol-induced myocardial infarction. Four different groups of rats (6 rats in each group) were taken; where group 1 comprised of normal untreated rats, group 2 was injected with Isoproterenol (synthetic catecholamine), group 3 was considered as standard and hence, was injected with Isoproterenol + Simvastatin and group 4 was treated with Isoproterenol + Sargassum wightii’s extract. Cardioprotective effects of Sargassum wightii was observed via the changes in the lipid profile, cardio marker enzymes and through histopathological studies. Rats treated with the extract of S. wightii showed a significant reduction in total cholesterol, LDL-cholesterol, serum triglycerides and increase in HDL- cholesterol level indicating an undamaged myocardial membrane. Likewise, low enzyme activity in Sargassum wightii treated rats clearly indicated the cardioprotective effects of Sargassum wightii. Histopathological studies were also done to observe the changes on the rats at the tissue level and no pathological changes were observed in Sargassum wightii treated rats. Hence, methanolic extract of Sargassum wightii is evidenced to possess cardioprotective activity against myocardial infarction.