Synthesis and antimicrobial activity of novel pyrazole nucleus containing 4-oxothiazolidine acetate derivatives

Abstract

A new series of 4-oxothiazolidin-5-ylidene acetates (4a–r) containing pyrazole moiety were designed and synthesized by using dimethyl acetylenedicarboxylate (DMAD) and diethyl acetylenedicarboxylate (DEAD) through a facile route involving regioselective heterocyclization. The synthesis was achieved at ambient temperature in good to excellent yields under catalyst free conditions. The newly synthesized compounds were examined for in-vitro antimicrobial activity against some anti-bacterial and fungal strains. The synthesized compounds were characterized by various spectral techniques including ¹H NMR, ¹³C NMR, IR, Mass, and elemental analyses.