“Design, synthesis and in vitro antimicrobial activity of furan-based pyrimidine-thiazolidinones as potential bioactive molecules”

Abstract

Antimicrobial resistance (AMR) to currently available antimicrobial drugs is a major source of worry for researchers. Antibiotic treatment is insufficient and ineffective against many bacteria and fungi as a result of antimicrobial resistance. Novel antimicrobial drugs that can successfully combat microbial resistance are urgently needed. In order to assess their antimicrobial activity, we developed and synthesized furan-based thiazolidinone and pyrimidine scaffolds (8a–8o). IR, ¹H NMR, and ¹³C NMR spectroscopy were used to characterize the structures of the newly synthesized analogues (8a–8o). The synthesized compounds have been tested for their antimicrobial properties against diverse bacterial and fungal strains. At MIC 12.5 μg/mL, compound (8a) shown efficacy against E. coli. At the same MIC of 50 μg/mL, compounds (8a) and (8o) shown efficacy against different bacterial strains against P. aeruginosa. At the same MIC of 100 μg/mL, the compounds (8d) and (8e) demonstrated strong fungal activity against A. niger. Using gentamycin, chloramphenicol, and ciprofloxacin, as reference drugs.