A Greener synthesis, molecular docking, antimicrobial and antimalarial activities of some unsaturated enones

Abstract

Some series of α, β-unsaturated ketones including isoquinoline enones were synthesised by Fly-ash:sulphated SnO₂ catalyzed Crossed-Aldol condensation of various aryl methyl ketones and aldehydes under solvent-free microwave irradiation technique.  In this synthetic methodology the obtained yield of the unsaturated ketones is more than 90%. The synthesised ketones were characterized by their physical constant’s micro analysis and spectroscopic data. The molecular docking, in-vitro antimicrobial and antimalarial activities of the synthesised ketones were studied.