The Synthesis, Spectral, Crystal, computational studies and antimicrobial activities of (E)-N-(substituted arylidene)-3-(trifluoromethyl)anilines

Synthesis, structural elucidatio, computational studies and antimicrobial activities of (E)-N-(substituted arylidene)-3-(trifluoromethyl)anilines

Abstract

A series of (E)-N-(substituted arylidene)-3-(trifluoromethyl) anilines were synthesised by ZnFe₂O₄ catalyzed microwave promoted condensation of 3-trifluoromethyl aniline and various aryl aldehydes. This condensation gave more than 90% yield of products. The synthesised imines were characterized by their analytical, micro analysis and spectroscopic data. From single crystal x-ray analysis, the structure of [(E)-N-(naphthalene-1-ylmethylene)-3-(trifluoromethyl) aniline was established.  The optimized geometrical structures, molecular electrostatic potentials of these amines were investigated by theoretical-computational and FMO study. The Mulliken charge analysis of these amines were predicted. In-vitro antimicrobial activities of prepared imines were assessed using Bauer-Kirby disc diffusion method.