Synthesis of novel glycosyl thiadiazole triazines and screening for antimicrobial activity

Abstract

In continuation to our search for a new bioactive potent molecule, we have synthesized several new 1-glycosyl-3-(5-phenyl-[1,3,4]thiadiazolyl)-carbamides by the interaction of various glycosyl isocyanates with 2-amino-5-phenyl-[1,3,4]-thiadiazole in acetone medium. Furthermore, several novel 6-glycosyl-2-phenyl-5-phenylimino-5,6-dihydro-[1,3,4]thiadiazolo [3,2-a][1,3,5]triazin-7-one have been synthesized by the interaction of phenyl isocyanodichloride and 1-glycosyl-3-(5-phenyl-[1,3,4]thiadiazolyl)-carbamides. The identities of these newly synthesized glycosyl carbamides and glycosyl thiadiazolo triazine have been established based on usual chemical transformations and IR, ¹H and ¹³C NMR and mass spectral studies and these will be assayed for their antibacterial activity against common pathogens like E. coli, S. aureus, P. vulgaris, S. typhi, K. pneumoniae, Pseudomonas aeruginosa and for antifungal activity against Aspergillus niger and Candida albican to get potent bioactive molecule.