Design and synthesis of phosphonate functionalized naphthalenediimide: Application to induce mitochondria mediated apoptosis in the human skin melanoma cells (SKMEL2)

Authors

  • Kiran R Kharat KETs V. G. Vaze College, Mulund, Mumbai 400 081, Maharashtra, India
  • Rajesh S Bhosale Department of Chemistry, Indrashil University, Rajpur, Mesana 382 470, Gujarat, India
  • Kamalakar P Nandre Polymers and Functional Materials Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, Telangana, India
  • Madan R Biradar Polymers and Functional Materials Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, Telangana, India ; Academy of Scientific and Innovative Research (AcSIR), CSIR-HRDC Campus, Postal Staff College Area Sector 19, Kamla Nehru Nagar, Ghaziabad 201 002, Uttar Pradesh, India
  • Sheshanath V Bhosale School of Chemical Sciences, Goa University, Taleigao Plateau, Goa 403 206, India
  • Sidhanath V Bhosale Polymers and Functional Materials Division, CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, Telangana, India; Academy of Scientific and Innovative Research (AcSIR), CSIR-HRDC Campus, Postal Staff College Area Sector 19, Kamla Nehru Nagar, Ghaziabad 201 002, Uttar Pradesh, India

DOI:

https://doi.org/10.56042/ijc.v62i5.1430

Keywords:

Phosphonate, Naphthalenediimide, Mitochondria, Apoptosis, SKMEL2

Abstract

New phosphonate functionalized naphthalenediimides (NDI-1 and NDI-2) have been synthesized and evaluated as potential drug candidates to treat the skin malignancy. The aforementioned candidates have resulted in an induced apoptosis pathway of cytotoxicity, at concentrations lower than 4 µM, in human skin melanoma cells, and elicited a stronger apoptotic response in cells. Regulation of the Bcl2, Caspases, Bak1, Bax protein in NDI-induced apoptosis in cells has been analyzed by real time PCR, and the cell viability and apoptosis determined by flow cytometry. The obtained results indicate that NDI-induced apoptosis by regulation of Bcl2 and Bak1 occurs in human skin melanoma cells (SKMEL-2).

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Published

2023-05-19

Issue

Vol. 62 No. 5 (2023): Indian Journal of Chemistry-(IJC)

Section

For Editors only

How to Cite

Design and synthesis of phosphonate functionalized naphthalenediimide: Application to induce mitochondria mediated apoptosis in the human skin melanoma cells (SKMEL2). (2023). Indian Journal of Chemistry (IJC), 62(5), 506-512. https://doi.org/10.56042/ijc.v62i5.1430