Antiproliferative and apoptotic effects of Lamium purpureum L. extract on prostate cancer cells

Lamium purpureum effect on prostate cancer

Abstract

The use of herbal agents in cancer treatment is an important concept. It is thought that the Lamiaceae family may have anticancer effects due to its polyphenol metabolites. The anticancer effect of the Lamium genus belonging to this family has been examined in some studies. However, there are few studies on the Lamium purpureum (purple dead-nettle) species. In this study, the Lamium purpureum extract/fractions were prepared in different solvents, and their effects on proliferation and apoptosis in the LNCaP prostate cancer cell line were examined in vitro. This was investigated using the CCK-8 test, JC-1 mitochondrial membrane potential assay, caspase 3/7 enzymatic activity test, and caspase-7 protein level by Western blot. It has been determined that Lamium purpureum ethanol extract suppresses cell proliferation with increasing concentration and may induce apoptosis via caspase-7. It is the first study to investigate the anticancer effect of Lamium purpureum on LNCaP cells.