Supramolecular assembly with Hydrogen bonded network solid formed by Reaction of Cyanuric chloride with Thiourea - Spectral and Anitmicrobial studies

Abstract

Interaction of thiourea (Tu) with cyanuric chloride (CC) in aqueous solution yielded a compound, (Tu)₂(CA)₂(NCS)(H₂O)₃, (CA-TU) (CA = cyanuric acid).The elemental composition, TG-DTA and mass spectrum confirmed the proposed composition.Infrared bands at 2026 cm^-1 and 1725 cm^-1 indicated -NCS and C=O  groups respectively along with the -OH and -NH stretching bands.¹HNMR indicated protonated H₂O (13.35 ppm) and N-H (6.05 - 7.01 ppm).The ¹³CNMR revealed -NCS carbon resonances at 116.99 ppm and at 178.83 ppm due to thiourea carbon.The signals at 150.39, 148.41 and 145.34 ppm are due to CA carbonyls.Thermal studies indicated that stepwise decomposition leading to NH₄NO₃ and then to nil residue.The compound is a supramolecular assembly of extensively H-bonded network work solid.The compound was found to be more effective towards Gram positive bacteria than Gram negative bacteria.The action is superior to fungi compared to that of the standard Amphotericin-B.The presence of sulphur and nitrogen moieties make it a good antifungal agent.