Synthesis , Characterization , Molecular docking study and Antimicrobial Activity of New 1,3,4-Oxadiazoles Bearing Isomeric Pyridyl and Thiazolyl Scaffolds

Abstract

In search of new antimicrobial agents, we report here a series new isomeric 2-pyridinyl substituted thiazolyl-5-aryl-1,3,4-oxadiazoles (2a-4g), using pyridine nitriles as a starting , following multistep synthetic route. An intermediate, pyridinyl substituted thiazolyl acid hydrazide when condensed with different para substituted benzoic acids  in the presence of POCl3 yielded better to excellent yields of the title compounds. All the synthesized compounds (2a-4g) have been screened for their in vitro antimicrobial activity. Amongst them, 3-pyridynyl and 4-pyridynyl derivatives are found to be more active than 2- pyridynyl derivatives.