Studies Directed Towards Synthesis of Leprostatic agent Desoxyfructoserotonin

Authors

  • Sreenivasulu Reddy Gopireddy Department of Chemistry, Jawaharlal Nehru Technological University, Anantapur-515002, Andhra Pradesh, India.
  • Kothapalli Bannoth Chandrasekhar Department of Chemistry, Jawaharlal Nehru Technological University, Anantapur-515002, Andhra Pradesh, India.
  • RANGANATH PLN Professor, Department of Pharmaceutical Chemistry, St.Johns College of Pharmaceutial Sciences, Yerrakota, Kurnool, Andhra Pradesh-518360 https://orcid.org/0000-0001-8909-9833

DOI:

https://doi.org/10.56042/ijc.v64i2.11734

Abstract

Leprosy is an infectious chronic disease and a neglected tropical disease induced by Mycobacterium leprae, and mainly affects the skin, peripheral nerves, upper respiratory mucosa and eyes. The prolonged physical deformities associated with leprosy get progressively worse with delayed diagnosis and increasing age. Desoxyfructoserotonin is a leprostatic agent, herein this paper we report its synthesis using 5-methoxy indole and the desired chiral centres was incorporated using naturally obtaing sugar moiety (D)-mannitol employing Vilsmeier- Haack reaction and Henry reactions.

Keywords: Hanson’s disease, Desoxyfructoserotonin, Vilsmeier-Haack reaction and Henry reactions

Author Biography

  • RANGANATH PLN, Professor, Department of Pharmaceutical Chemistry, St.Johns College of Pharmaceutial Sciences, Yerrakota, Kurnool, Andhra Pradesh-518360

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Published

2025-02-20

Issue

Vol. 64 No. 2 (2025): Indian Journal of Chemistry-(IJC)

Section

Papers

How to Cite

Studies Directed Towards Synthesis of Leprostatic agent Desoxyfructoserotonin. (2025). Indian Journal of Chemistry (IJC), 64(2), 148-153. https://doi.org/10.56042/ijc.v64i2.11734