A A Highly Efficient Route for Synthesis of N-Hydroxymethyl Sumatriptan and Sumatriptan Dimer; Impurity C and H of Anti-migraine drug Sumatriptan.

Synthesis of Sumatriptan Impurity C and H of Anti-migraine drug Sumatriptan.

Abstract

This research work describes a highly efficient route for the synthesis and characterization of the two potential Sumatriptan impurities; N-Hydroxymethyl Sumatriptan (Impurity C) and Sumatriptan Dimer (Impurity H). The purity of the synthesized impurities was confirmed using HPLC, and their structures were identified by using MS, ¹H NMR spectroscopy.