Biopotential insights and structural chemistry of some zirconocene incorporated heterocyclic β-diketones and flexible N-protected α/β- amino acids

Abstract

The interaction of zirconocene dichloride with the heterocyclic β-diketones (LH) and flexible N-protected α/ β-amino acids (AH) in the presence of triethylamine in 1:1:1:2 molar ratio in refluxing dry THF has been resulted in the formation of zirconocene complexes of the general formula (where R= -CH₃, -CH₂CH₃, p-ClC₆H₄-, -C₆H₅ and CHR’ = -CH₂CH₂and R’ = CH(CH₃)₂). These newly generated zirconocene incorporated organic-inorganic hybrid products have been characterized by FTIR, NMR (¹H and ¹³C) and mass spectrometry. Some of these complexes and their corresponding ligands have been tested for their antimicrobial activity to examine the biopotential activity-structure relationship.