Synthesis and characterization of H-cardanol incorporated C(3)-aminoisoindolinones

Abstract

A facile and high-yielding synthesis of the hydrophobic and the hexane soluble H-cardanol incorporated C(3)-aminoisoindolinones has been successfully achieved. Additionally, the synthesis of the H-cardanol embedded tetracyclic C(3)-aminoisoindolinones has also been successfully achieved. The H‑cardanol incorporated isoindolinones are low melting, lipophilic solids and readily soluble in hydrocarbon solvents - a property useful for topical administration of medicinal drugs. The UV-Vis spectra of the C(3)-aminoisoindolinones with two H-cardanol units do not indicate an intramolecular association between the two aromatic rings.