Synthesis, Structure and Biological Ability of Organotin Carboxylate Derived From Modified Amino Benzo Thiozole

Abstract

A novel ligand, 2-[(1,3-benzothiozol -2-yl) amino] acetic acid (BAA), was prepared by condensation reaction of 2-aminobenzothiozole with chloro acetic acid. BAA prepared ligand was applied to prepare three different organotin carboxylate complexes via condensation reactions with a salts of corresponding organotin(IV) chloride. The synthesized ligand BAA and complexes were systematically identified via the use of Fourier transform infrared spectroscopy (FTIR), multinuclear magnetic resonance spectroscopy ( proton and ¹¹⁹Tin- NMR), and carbon (C), hydrogen (H) and nitrogen (N) elemental analysis, checking their fundamental integrity. BAA antioxidant ability and their organotin(IV) carboxylate complexes was estimated via different established methods: CUPRAC (Cu ion Reducing Antioxidant Capacity) and DPPH (2, 2- diphenyl-1- picrylhydrazyl) radical scavenging assays. Results pointed that all organotin(IV) carboxylate complexes showed significantly larger inhibition percentages contrasted with free BAA ligand, underlining the serious role of the Tin(IV) centers in rising antioxidant ability. Particularly, the Ph₃Sn(IV)COO-complex proved superior functioning at both method, assigned to its noticeable steric and electronic properties resulting from the Ph₃ groups substituents.