Synthesis, antimicrobial and antimalarial activity of novel Carbazole derivatives

Abstract

1-((9H-carbazol-4-yl)oxy)-3-(piperazine-1-yl) propane-2-ol 3 was synthesized by condensing Epoxy carbazole 1 and piperazine 2. 2-(4-(3-((9H-carbazol-4-yl)oxy)-2-hydroxypropyl)piperazin-1-yl)-1-phenylpropan-1-one 5a – 5c derivatives were synthesized by using 1-((9H-carbazol-4-yl)oxy)-3-(piperazin-1-yl)propan-2-ol 3 and different derivatives of 2-bromo-1-phenylpropan-1-one 4a–4c. IR, ¹HNMR, ¹³C NMR, Mass spectroscopy & C, H, N analysis elucidated the structures of compounds. The title compounds were explored to antimalarial & antibacterial activity and exhibits promising result.