Synthesis, Characterisation, Biological activity of Zn, Co, Ni, Mn and Cu complexes with hydrazone ligand

Synthesis, Characterisation of complexes with hydrazone ligand

Abstract

The heterocyclic ring system or DHA derivatives possessed strong chelating aspects with numerous metal ions as well as excellent anti-microbial properties, such as DNA binding and cleaving, anti-fungal, anti-bacterial, anti-cancer, and anti-viral. Schiff's base metal complexes of the pyrimidine heterocyclic system and dehydroacetic acid (DHA) with Co²⁺, Ni²⁺, Cu²⁺, Mn²⁺, and Zn²⁺ ions were synthesized in the current study. The produced metal complexes of Co²⁺, Ni²⁺, Cu²⁺, Mn²⁺ and Zn²⁺ ions coordinate with the hydrazone ligand via O and N donor atoms with deprotonation of the -OH functional group, according to the ¹H NMR, Mass, UV and FT-IR spectrum data. The ratio of the ligand to the metal salts was determined to be 1:2 based on mass spectral data. Cu²⁺ and Zn²⁺ metal complexes that were synthesized were discovered to have outstanding antibacterial activity. In compared to free hydrazone, all of the additional metal complexes had excellent antibacterial properties.