Applications of oxidative and reductive methodologies on coumarinyl ketones

Abstract

The higher degree of chemoselctivitiy and regioselectivity recorded during the selenium dioxide oxidation on various coumarinyl Ketones (1 -7) afforded the corresponding coumarinyl α-di carbonyl compounds (1a-7a &5b) in which the compound (2a) was isolated as an unexpected product and also the sodium borohydride reduction of coumarinyl Ketones (1-14) afforded the desired coumarinyl carbinols (1c-3c,5c,7c-9c,11c &13c) and 5-keto-6-hydroxy-cinnamic acid derivatives (4d,6d,10d,12d&14d) as an unexpected products in minor amount.