Synthesis and antituberculosis action of symmetric acridin-9-yl-bis-benzothiazol-2-yl-amines

Abstract

A new series of symmetric acridin-9-yl-bis-benzothiazol-2-yl-amines have been synthesized in good-excellent yields by intra-molecular cyclization of 1-acridin-9-yl-1-benzothiazol-2-yl-3-aryl thiourea and screened for their in vitro antitubercular activity against Mycobacterium tuberculosis by BACTEC radiometric method. The synthesis of new analogues bearing an acridine-linked chloro-substituted benzothiazole demonstrated enhanced antituberculosis activity.

Keywords:    Tuberculosis, acridine, benzothiazole