Copper (II) complexes supported by phenyl selanyl ligands: DNA binding and molecular docking studies

Abstract

Copper II complexes (3a-d) with (16E) -2,6-dimethyl-N-(2-phenylquinoline-4(1H)-ylidene)-5-(phenylselanyl) pyrimidine-4-amine ligands have been developed. They have been characterised by elemental analysis and several spectroscopic studies. Absorption spectra, fluroscence investigations, and viscosity tests reveal how the copper complexes interact with the calf thymus (CT-DNA). Furthermore, the ligand's ability to inhibit acetylcholinesterase (AChE) has been studied in order to establish its efficacy in the treatment of neurodegenerative diseases. Compared to normal Rivastigmine and Galantamine, the synthesised ligand 2c shows selective inhibition (AChE and BuChE) with IC50 values of 0.18 and 3.03 μM. A molecular docking study was carried out.