Antituberculosis activity of α-aminoacyl amide derivatives

Abstract

The preparation and evaluation of α-aminoacyl amides derivatives against M. tuberculosis H37Rv is reported. The systematic modifications of hit compound were carried out. Compounds 19b and 19c are identified as potent and selective inhibitors of M. tuberculosis H37Rv with MIC 2.5 µM and 2.6 µM respectively. Compounds 19b and 19c hold a promise for further development to discover new potent antituberculosis lead.