Lewis Acid-Promoted Synthesis of 3-Tosylisoindolinone from 3-Hydroxyisoindolinone: Access to Complex Furopyrroloisoindoledione

Abstract

An efficient methodology has been developed for the synthesis of sulfur-functionalized isoindolone scaffold from hydroxyisoindolinone via N-acyliminium ion intermediate using TosMIC and Lewis acid in good to excellent yields. The strategy features mild reaction conditions, broad substrate scope, metal-free reaction method. The protocol has been extended for the synthesis of complex furopyrroloisoindoledione derivatives.