The Synthesis, molecular docking, and pharmacological evaluation of some new triphenyl imidazole derivatives as anxiolytic agents

Synthesis of triphenylimidazole derivatives bearing anilines as anxiolytic agents.

Abstract

In the present investigation the docking of triphenyl imidazole derivatives were done following to which synthesis of the compounds were carried out and the compounds were characterized by TLC, IR, and ¹HNMR. The compounds were assessed in-vivo for antianxiety activity by two different methods. Other parameters were also assessed including similarity index and Log P values which was found to be in range which indicate that drug penetration to CNS is good. Among the synthesized derivatives the compound NS-3 and NS-4 gives remarkable anxiolytic activity.  The studies of molecular docking studies displayed that the compounds appropriately docked into binding pocket of the GABA_A receptor and bioavailability/drug-likeness was also predicted to be satisfactory warranting forthcoming exploration. The further prospect is to optimize the synthesized derivatives to engender new moieties for treatment of anxiety.