A A new approach for the synthesis of strobilurin fungicide analogous: Synthesis, characterization, antifungal study and molecular docking investigation

synthesis of strobilurin fungicide analogous synthesis, characterization and molecular docking investigation

Abstract

As an effort to protect plants from fungal diseases and to enhance the stability of the strobilurin fungicides, herein we report an efficient and simple approach for the synthesis of strobilurin fungicide analogous. The synthesised compounds were characterised by IR, NMR and LC-MS spectroscopic techniques. The antifungal efficacies of the synthesised compounds were tested against plant pathogens namely Curvularialunata, Rhizoctonia solani and Sclerotium rolfsii by using poison food/pour plate and spore germination methods.  Azoxystrobin and Tebuconazole were used as standards in the analysis. Further, the synthesized compounds were subjected to in silico studies to know the bonding interactions with bovine cytochrome Bc1 and CYP51 protein of cytochrome 450.