A Thermal and Biological appraisal on Cu (II) Based Complexes using Ciprofloxacin with Bromo-dicumarol derivative

Thermal and Biological appraisal on Cu (II) Based Complexes using Ciprofloxacin with Bromo-dicumarol derivative

Abstract

A series of novel Cu (II) complexes were produced using the conventional thermal method. The biologically active ligands (L) were created by refluxing a dicumarol derivative with aldehydes in ethanol. The Cu (II) compounds were synthesized by mixing an aqueous solution of the metal in a 1:1 molar ratio with ethanolic ligands and modified ciprofloxacin. The structures of the ligands and their copper complexes were analyzed and confirmed through fundamental analysis, FT-IR, ¹H-NMR, ¹³C-NMR, and mass spectrometry. The thermal properties of the newly synthesized mixed-phase Cu (II) complexes were investigated using thermo gravimetric analysis. Both the ligands and their complexes were screened for their in vitro inhibition, anti-tubercular, and antimicrobial activities, which were significantly potent compared to the parent ligands used for complexation.