Design, synthesis, characterization and biological evaluation, of novel N-substituted 1,2,3,4-tetrahydropyrimidines-5-carboxamide derivatives

f novel N-substituted 1,2,3,4-tetrahydropyrimidines-5-carboxamide derivatives

Abstract

The synthesis of 5-[N-(substitutedphenyl)]-carboxamido-1,2,3,6-tetrahydro-1,4-dimethyl-2-oxo-6-(m-phenoxyphenyl)-pyrimidines (4_a-j) have been synthesised by the condensation of m-phenoxybenzaldehyade, N-(4-substitutedphenyl)-oxobutanamides and N-methyl urea in presence of catalytic amount of acid.