An experimental insight into biological potent macrocyclic complexes: Template synthesis and biological studies

Abstract

Due to arising of problem of antimicrobial resistance now a days, it is the requirement to develop novel antimicrobial agents. In the present research work we reported the preparation of macrocyclic divalent transition metal complexes by adopting the path of template methodology. The bivalent 3d-transition metal salts used are Co^II, Ni^II , Cu^II and Zn^II in their chloride form. The macrocyclic ligand is derived in situ by the help of 3,4-Diaminotoluene and Thiobarbituric acid. The synthesised complexes were fully characterised and analysed by the assistance of spectroscopic and physico-analytical techniques like IR, NMR, Electronic spectra, Electron Spray Ionisation-Mass Spectrometry, Electron Spin Resonance, CHN, Molar conductance and magnetic moment measurements. The selected analyses reveal that the macrocyclic complexes may be verbalized as [MLX₂], where M is the divalent transition metal ion, L is the macrocyclic ligand and X is the counter ion of the metal salt. The Infra red spectral studies help in the primary identification for the successful development of macrocyclic complexes by the condensation reaction. The monomeric behaviour of the prepared compounds were explicated by the Mass Spectrometric and elemental analysis data. The geometry proposed was distorted octahedral in nature for all the metal complexes on the basis of results obtained from the Electronic spectra and ESR studies. Lower values of the molar conductance points in the direction of the non-electrolytic expression of the complexes. All the synthesised metal complexes were unveiled for their antifungal and antibacterial efficacies contrary to some fungal and bacterial strains. In addition to this, we have also performed the in silico ADME studies for the determination of various pharmacokinetic parameters that help in interpreting the dug like properties in the complexes.