Synthesis of novel nanosized pharmacologically active macrocyclic complexes as efficient biomaterial

Abstract

Antimicrobial resistance is becoming prominent issues nowadays. Because of the requirement of new antimicrobial compounds a series of novel macrocyclic complexes of Ni^II and Cu^II with sulphur and nitrogen containing ligand have been prepared by divalent transition metal ion-mediated template method. The macrocyclic ligand is derived from the 4,6-Dihydroxy-2-mercaptopyrimidine (DMP) and thiosemicarbazide (TSC). Various physico-analytical and spectroscopic techniques like Infra-red spectroscopy, Electron Spray Ionisation-MS, Elemental analysis, UV-visible, EPR, Magnetic moment measurements and Molar conductivities were used for the structural depiction of the newly synthesized metal complexes. The assistance of PX-Ray-D technique was taken for the morphological study of Ni^II complex. Minimization of energy and numerous parameters for quantum chemical were calculated using the Gaussian 09 program. Based on several characterization,distorted octahedral geometries have been projected for all the metal complexes with assigned molecular formula [M (C₁₀H₁₄N₁₀S₄) X₂] where X= Cl^-, NO₃^- and CH₃COO^-. All the newly prepared metal complexes were screened for their bio-efficacy against some pathogenic strains of bacteria and fungus. In silico molecular docking studies were also performed against SARS- Cov-2 protein.