Combined therapeutic potential of kiwi leaf extract and Epigallocatechin gallate on A549 lung cancer cell line

Abstract

In this study, Epigallocatechin gallate (EGCG) was extracted using an aqueous extract from kiwi leaves
(Actinidia deliciosa) to explore an alternative to traditional extraction methods such as citric acid and two-step extraction. The objective was to evaluate the combined therapeutic effects of kiwi leaf extract and EGCG on the A549 lung cancer cell line. Rich in bioactive compounds, kiwi leaves may enhance the anticancer efficacy of EGCG, a polyphenol found in green tea, strawberries, and other plants, known for its ability to inhibit cancer cell proliferation. Cell-based assays were employed to assess cell viability, apoptosis, and migration inhibition, while molecular analysis focused on signaling pathways involved in cancer progression. The findings highlight the potential of natural plant-based compounds, particularly kiwi leaf extract, in enhancing the therapeutic impact of EGCG. This combination may offer a promising strategy for lung cancer treatment by improving drug effectiveness and reducing side effects. Overall, this study provides innovative insight into the synergistic potential of kiwi leaf extract and EGCG as a natural and effective approach to lung cancer therapy.