In silico study of 4-amino substituted-7-chloroquinoline derivatives as Plasmodium falciparum lactate dehydrogenase inhibitors
DOI:
https://doi.org/10.56042/ijbb.v61i7.953Keywords:
1LDG, 4-amino substituted-7-chloroquinolines, Docking and ADME, Malaria, Plasmodium falciparum lactate dehydrogenaseAbstract
The docking between 4-amino substituted-7-chloroquinoline derivatives and Plasmodium falciparum lactate dehydrogenase were carried out. The designed 4-aminosubstitued-7-chloroquinoline derivatives show comparable dock score with chloroquine. The docking study reveals that the binding of 4-amino substituted-7-chloroquinoline derivatives and amino acids in the binding pocket of Plasmodium falciparum lactate dehydrogenase is observed. Predicted ADME properties of designed compounds are in range.
Published
2024-06-25
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Copyright (c) 2024 Indian Journal of Biochemistry and Biophysics (IJBB)
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How to Cite
In silico study of 4-amino substituted-7-chloroquinoline derivatives as Plasmodium falciparum lactate dehydrogenase inhibitors. (2024). Indian Journal of Biochemistry and Biophysics (IJBB), 61(7), 443-446. https://doi.org/10.56042/ijbb.v61i7.953
