Plastic orchiectomy and some indicators of improvement of vital parameters and general condition of the organism in blood of the men with prostate cancer

Abstract

Prostate cancer (PCa) is the most common malignancy affecting men in developed countries. Prostate gland cells, normal or cancerous, are dependent upon androgens for survival and growth. Consequently, androgen deprivation therapy (ADT) is still the mainstay for PCa treatment. Recent studies revealed that in comparison with pharmaceutical approaches, surgical castration may be associated with significantly lower risks of peripheral arterial disease and cardiac-related complications compared to chemical castration. Thus, our present research work aimed to investigate potential alterations in lipid components, in particular the amount of phospholipids, cholesterol and free fatty acids in the blood of the men with prostate adenocarcinoma before and after plastic orchiectomy in order to demonstrate the contribution of these changes in PCa progression. We also studied the activities of antioxidant enzyme - superoxide dismutase (SOD) and prostatic acid phosphatase (PAP) to estimate general condition of an organism. Revealed alterations in lipid spectrum components (quantitative changes in the amounts of phospholipids, cholesterol, and fatty acids) before and after plastic orchiectomy indicates on remodeling of lipid metabolism after plastic orchiectomy. Approximation of total cholesterol and phospholipids levels to control group indices together with the reduced amounts of fatty acids indicates on the regression of the pathology for a certain period of time (~6-18 months). Furthermore, increased activity of SOD and sharply reduced activity of acid phosphatase after plastic orchiectomy must be the indicators for improvement of general condition of the body.