Progress and future challenges in gene vectors, gene therapy systems and gene expressions

Authors

  • Dhinakaran Veeman 1Centre for Additive Manufacturing, Chennai Institute of Technology, Chennai-600 069, Tamil Nadu, India
  • Duraisami Dhamodharan 2Greenlab, Department of Prosthodontics, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai-600077, Tamil Nadu, India
  • M Varsha Shree 1Centre for Additive Manufacturing, Chennai Institute of Technology, Chennai-600 069, Tamil Nadu, India
  • L Natrayan 3Department of Mechanical Engineering, Saveetha School of Engineering, SIMATS, Chennai-602 105, Tamil Nadu, India
  • B Stalin 4Department of Mechanical Engineering, Anna University, Regional Campus Madurai, Madurai-625 019, Tamil Nadu, India
  • Shanmugam Ramaswamy 5TIFAC, CORE-HD, Department of Pharmacognosy, JSS College of Pharmacy, JSS Academy of Higher Education & Research, Ooty-643 001, Tamil Nadu, India
  • Leta Tesfaye Jule 6Department of Physics, College of Natural and Computational Science; 7Centre for Excellence-Indigenous Knowledge, Innovative Technology Transfer and Entrepreneurship, College of Engineering and Technology, Dambi Dollo University, Ethiopia
  • R Krishnaraj 7Centre for Excellence-Indigenous Knowledge, Innovative Technology Transfer and Entrepreneurship; & 8Department of Mechanical Engineering, College of Engineering and Technology, Dambi Dollo University, Ethiopia

DOI:

https://doi.org/10.56042/ijbb.v59i11.58757

Keywords:

Gene expressions, Gene targeting, Gene therapy, Vectors

Abstract

Genetic engineering has made sizeable contributions to technical innovation, agriculture, and the development of pharmaceuticals. Various approaches were evolved to control the genetic cloth of cells using both viral and nonviral vector architectures. Gene therapy aims to reverse pathological traits with the aid of the use of viral and nonviral gene shipping mechanisms. Gene transfer motors have made massive strides in becoming more environmentally pleasant, much less risky, and nonimmunogenic, as well as making an allowance for lengthy-time period transgene expression. One of the most tough components of correctly enforcing gene healing treatments in the clinical putting is adjusting gene expression extremely tightly and constantly as and while it's required. This research work will cognizance on using viral vectors for gene concentrated on biological applications with various gene expressions. Due to improvements in viral vector engineering and superior gene regulatory systems to permit and adjust tightly therapeutic gene expression, the technology for using genes to offer a preferred treatment has confirmed to be an effective approach

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Published

2023-06-22

Issue

Section

Review

How to Cite

Progress and future challenges in gene vectors, gene therapy systems and gene expressions. (2023). Indian Journal of Biochemistry and Biophysics (IJBB), 59(11), 1027-1038. https://doi.org/10.56042/ijbb.v59i11.58757

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