Effect of butylphthalide combined with ozagrel sodium on cerebral perfusion and oxidative stress indexes in patients with transient ischemic attack

Abstract

This study has been undertaken to evaluate the effect of butylphthalide combined with ozagrel sodium on cerebral perfusion and oxidative stress indexes in patients with transient ischemic attack. In this study, a total of 116 patients diagnosed as transient ischemic attack in our hospital (February 2018-February 2020) have been selected and divided into two groups according to the treatment methods.58 cases in the control group have been treated with ozagrel sodium, 58 cases in the observation group have been treated with butylphthalide combined with ozagrelsodium. The CT perfusion imaging parameters, oxidative stress indexes, plaque area, and the levels of platelet activating factor (PAF), α-granule membrane protein-140 (GMP-140), fibrinogen (FIB), platelet aggregation rate (PAgT), neuron-specific enolase (NSE), oxygen-inducible factor-1α ( HIF-1α ), and matrix metalloproteinases-9 ( MMP-9) in the two groups have been recorded, and the total effective rate and adverse reaction rate have been counted. The results shown that the total effective rate of the observation group is higher than that of the control group, and the difference is statistically significant (χ² = 4.640,
P = 0.031). The average time (MTT) required for the two groups of contrast agents to pass through the local brain tissue and the time (TTP) required starting the injection of contrast agents to reach the peak concentration decreased compared to that with before treatment. After treatment, the MTT and TTP of the observation group are shorter than those of the control group (P < 0.05). Compared with before treatment, superoxide dismutase (SOD) in the two groups has higher than that in the control group, PAF, GMP-140, FIB, PAgT, NSE, HIF-1α, MMP-9, malondialdehyde (MDA) and plaque area has decreased. After treatment, the levels of related factors in the observation group are better than those in the control group, and the plaque area is less than that in the control group (P < 0.05).There has been no significant difference in the adverse reaction rate between the observation group and the control group (χ² = 0.438, P = 0.508).