In-vitro studies of bioactive nanoemulgel from agro-waste and mathematical modeling of drug release

Abstract

A comparison of the bioactive components present in the 1:16 (% w/v) ethanol extracts of rinds of Citrus limetta, Punica granatum and leaves of Musa acuminata have been carried out. The leaf extract of Musa acuminata revealed the presence of about 88% of components with antimicrobial activities. The current work focuses on a comparative study of fitness of empirical (Zero, First, Higuchi) and semi empirical (Ritger-Peppas) mathematical models to describe the drug release mechanism of the formulated nanoemulgel. In-vitro studies are carried out, of which B1 posed 96% of cumulative drug release. The results revealed that Higuchi model fitted the best for the optimized formulation of B1, B2, and B3 with higher regression coefficient (R² values of 0.99). The formulation followed the Fickian type of release for the bioactive component, which can be used for treating the fungal infection.