A new Ca(II) coordination polymer: Structural characterization and treatment activity on childhood asthma

Abstract

In the present study, a 3D coordination polymer with the chemical composition of[(CH₃)₂NH₂][Ca(tcpbH)(H₂O)] (1) has been solvothermally obtained from a rigid tetracarboxylic acid ligand tetrakis-(4-carboxyphenyl)benzene (H₄tcpb) and alkaline-earth ion Ca^II. Complex 1 has been well studied via Fourier-transform infrared spectroscopy, elemental analysis (EA), TG analysis and single-crystal X-ray diffraction analysis. Its application values on the childhood asthma were determined and the internal principle has been discussed simultaneously. Firstly, the ELISA is utilized to measure the content of inflammatory cytokines released into the Broncho alveolar lavage fluid (BALF) after compound treatment. In addition to this, the real time RT-PCR was conducted to measure the relative expression levels of NF-κB signaling pathway in the alveolar epithelial cells.