Design and Synthesis of Some Novel 1-chloro-6-(4-(sulfonyl) piperidin-4-yl) phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-5-ones as In Vitro Anticancer Agents

Novel 1-chloro-6-(4-(sulfonyl) piperidin-4-yl) phenyl)-6,7-dihydro-5H-cyclopenta[c]pyridin-5-ones as In Vitro Anticancer Agents

Abstract

The multi-step synthesis and structural determination by ¹HNMR, ¹³CNMR, IR, and mass investigations of certain new piperidinyl-pyridines (10a-o) are described in this article. Compounds 10e, 10g, 10h, 10i, 10j, and 10n showed greater efficacy with Doxorubicin, which is employed as a positive control, when tested for anti-cancer activity in vitro against two cancer cell lines, A549& MCF-7. 10g showed promising action over A549 and MCF-7, with IC50 values of 16.3 and 12.3 M respectively. Other IC50 values showed strong promise and were similarly in the good promise range.